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KMID : 1123920020160051020
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 5 p.1020 ~ p.1024
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Effect of Kamidaebo-tang on Murine Peritoneal Macrophages
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Song Jeong-Mo
Oh Chan-Ho
So June-No
Kim Dae-Keun
Eun Jae-Soon
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Abstract
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The purpose of this research was to investigate the effects of Kamidaebo-tang water extract (KDT) on murine peritoneal macrophages. KDT (50 or 250 mg/kg) was administerd p.o. once a day for 7 days to mice. KDT increased the production of tumor necrosis factor-α and nitric oxide from murine peritoneal macrophages, but decreased the production of interleukin-1β. Also, KDT enhanced the production of lucigenin chemiluminescence from peritoneal macrophages. These results suggest that KDT enhances the non-specific immune response via increase of tumor necrosis factor-α and nitric oxide and phagocytic activity from peritoneal macrophages.
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KEYWORD
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Kamidaebo-tang(加味大補湯), cytokine, peritoneal macrophage, phagocytosis
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